| 英文摘要 |
Lung cancer is an important disease with a very high fatality rate in many countries. There have been many investigations on the risk factors of lung cancer. The effects of active and passive cigarette smoking are of most concern. The association between pulmonary tuberculosis and lung cancer has been discussed since more than 100 years ago, but remains controversial. The purpose of this study was to evaluate the relationship of pulmonary tuberculosis and lung cancer. We recruited 287 lung cancer inpatients from three different hospitals in Taipei City as a case group, 584 inpatients from the Departments of Internal Medicine and Family Medicine of the study hospitals and 542 residents from the community as hospital controls and community controls, respectively. Cases and controls were matched for age, sex, and residential area. The results showed that males who had a history of pulmonary tuberculosis had 21.0 and 9.5 times the risk of lung cancer of those who had never been affected with pulmonary tuberculosis from the hospital and community samples, respectively Females who had a history of pulmonary tuberculosis had 42.1 times the risk of lung cancer of those without it as compared to the community controls. The effect of tuberculosis on lung cancer remained statistically significant after adjustment for cigarette smoking and other factors, including drinking habit, vitamine intake, and intake of smoked foods. The further investigation should focus on the role of pulmonary tuberculosis in the development of lung cancer. |
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