With the increasing interaction across Taiwan straits, the Mainland China female spouses became a major immigrant group in Taiwan. In the first few years requiring energy to adjust their new life, they soon became mothers of young children. When they had children with special needs, it was no doubt a double load for them. To support mothers from Mainland China who had children with special needs might require deeper understandings of how they faced their challenges, what factors affected their adjustment, and what their needs were. A qualitative research design with semi-structured, in-depth interviews and participant observation were applied. Results of this study revealed that: (1) Eleven mothers of children with special needs affirmed the effectiveness of early intervention. However, it was worth noting that seven (58.3%) participants whose children appeared abnormal during pregnancy or after birth, had experienced a long period of helplessness. (2) Although the mothers of children with special needs often lacked information or support, they still showed great perseverance in the face of difficulty and took a lot of time and effort to assist in the rehabilitation services and schooling of their children. Only one child who lived on the mountain didn't receive rehabilitation because of inaccessibility of transportation. (3) One mother who had received early intervention in both Mainland China and Taiwan noted that the early intervention systems in Mainland China were more efficient from diagnosis, evaluation to rehabilitation. On the other hand, the equipments and welfare in Taiwan were better, but it took time to receive early intervention services. (4) Six mothers of children in early intervention or special education classes were content with their children's progress, while other mothers whose children were not in these settings showed concerns about their children's future. In regard to the findings of support systems and needs: (1) Mainland China mothers had various kinds of support from social workers, teachers, relatives, other parents and churches, etc. (2) They needed more support in child care and finance, and had concerns about their children's educational placement and adjustment in the future.