Due to the quickly changing of information and technology, information literacy skills have been required for respiratory therapists to maintain daily practice in healthcare facilities. Most importantly, these skills are able to be developed to meet job demands from tertiary education. The purpose of this cross-sectional study was to investigate the competencies of informatics literacy and their related influencing factors on undergraduate students of respiratory care. According to current research on informatics literacy, respiratory students are required to have three essential skills of information literacy: informatics knowledge, informatics skills, and informatics attitudes. The research subjects were undergraduate students of respiratory care at a university of science and technology located in southern Taiwan. Out of a total of 170 copies, 162 responses to the questionnaire were received (response rate was 95.3%); the Cronbach's α value was .805~.945 and factor loading value was .085~.794. The results showed that the competencies of information literacy were closely correlated to the personal background. Analysis on information literacy revealed significant differences in educational background of parents, the number of computers with internet access, and the daily amount of time on the internet surfing. This paper is hoped to serve as a reference for educators to improve information literacy of students by designing and developing the informatics courses in the future.