| 中文摘要 |
三消草Ruellia tuberosa L. 為爵床科（Acanthaceae ）植物，因具有治療消渴症功效以取名消渴草。經甲醇萃取濃縮後，藉由一系列分離得到五個類黃酮成分 cirsimaritin （1） 、cirsimarin （2） 、cirsiliol 4′-glucoside （3） 、sorbifolin （4） 及pedalitin （5） ，和三個化合物 betulin, vanillic acid, indole-3-carboxaldehyde 。各成分之結構係由紅外線、質譜及核磁共振等光譜的分析而確認。其中化合物1 和3 對KB 腫瘤細胞有抑制效果，其IC50 分別為30.05 及17.91 μg/mL ；而化合物2 則對HepG2cell 有抑制效果，其IC50 為38.83 μg/mL 。Five flavonoids cirsimaritin (1), cirsimarin (2), cirsiliol 4′-glucoside (3), sorbifolin (4), and pedalitin (5) along with betulin, vanillic acid, and indole-3-carboxaldehyde were isolated from the EtOAc extracts of Ruellia tuberosa. The structures of all eight compounds were elucidated by IR, MS, and NMR spectral data. Compounds 1 and 3 showed cytotoxicity against KB cell line with the IC50 values of 30.05 and 17.91 μg/mL, respectively, while compound 2 was cytotoxic against HepG2 cell line with an IC50 value of 38.83 μg/mL. |
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