刺五加自古以來是我國一種常用的藥材，屬於補氣藥，具有補虛扶弱的功效。本研究探討補充刺五加八週對人體之抗疲勞功能。18 名健康男女大學生為受試者，以雙盲隨機抽樣方式分為二組：實驗組9 名，每天服用刺五加乙醇抽出物600 毫克；安慰劑組9 名，每天服用澱粉安慰劑。受試者於服用八週前後作電動原地腳踏車運動，直至力竭為止，於運動前中後抽血。結果顯示服用刺五加八週後，耐力運動持續時間延長30% ，高強度負荷運動中最大心跳率增加4% ，運動後游離脂肪酸增加20% ，血乳酸下降18% ，且均達統計上之差異（p < 0.05 ）；本研究結論為：攝取中藥刺五加乙醇抽出物600 毫克八週能增強人體有氧能力，延長耐力運動時間，對人體具抗疲勞功能。推薦刺五加可作為耐力型運動員的有效營養性增補劑。Radix Acanthopanacis Senticosi (RAS) has been used to increasing energy and vitality for over 2,000 years in Chinese medicine. This study examined the effects of oral RAS supplementation on antifatigue function for 8 weeks. Eighteen healthy male and female college students successfully completed the trial, after randomly receiving in a double-blind design an oral dose of 600 mg RAS or placebo (P). Subjects did the cycling exhaustion exercise tests, which at baseline and after 8 weeks of daily supplementation. Blood parameters were collected before, between and after each exhaustion exercise trial. Statistical analyses showed significant differences (p < 0.05) between the RAS and P groups at the endurance exercise time increased 30% and the HRmax increased 4%. After the exhaustion exercise, blood lactic acid decreased 18% and 20% increased in blood free fatty acid. We conclude that oral Radix Acanthopanacis Senticosi supplementation 600 mg per day for 8 weeks may enhance aerobic capacity, increase endurance exercise time, and has anti-fatigue effects in human. We recommend Radix Acanthopanacis Senticosi as an effective nutritional ergogenic aids for the endurance athletes.