This study investigates the therapeutic effects of fractionated irradiation (RT) and moxibustion (MT) on ICR-strain male mice with tumors. Ehrlich ascites tumor cells (10) were implanted into the subcutaneous tissue of thigh area. When the volume of the tumor grew up to 0.45±0.2cm^3 in subcutaneous tumor of mice, animals with tumors were divided into many groups. The experimental groups were treated with RT or/and MT. Changes of temperature in the tumor and normal tissue surrounding tumor were measured by thermal probe during moxibustion treatment. The body weight, tumor size, mortality rate (MR), tumor control rate (TCR) and mean survival time (MST) within 120 days in each group of mice after treatment were measured. The results revealed that the temperature in tumors under 2,10 mm from surface were 63±3.4℃ and 45±2.5℃ respectively and the temperature in normal tissue around tumor was 37℃ during moxibustion treatment. The results showed that the best therapeutic effect in single treatment was the group treated with direct moxibustion (DM) in 2 or 3 fractions. The TCR, MR and MST in these groups were 100%, 0% and 120 days respectively. Good therapeutic effect was also observed in the group treated with a combination of DM (1) and RT. The TCR, MR and MST in this group were 100%, 9% and 117.7 days respectively. The results of this experiment show that the effect of MT with hyperthermia can enhance radiation in tumor treatment.