台灣產海桐高氧化型三萜類之研究

Highly Oxygenated Triterpeneoids from Pittosporum Tobira Ait.

海桐(Pittosporum tobira AIT)係海桐之植物。為產於本島之海岸常綠灌木。台灣民間將本植物以水煎服，具殺菌和降血壓之效。莖葉之水萃取物亦具驅蟲之效果。根據廖琴等人之研究可使腎型高血壓大白鼠之血壓降低。根據Yosioka等之報導其含Ursolic acid、21β-O-angeloyl-R barrigenal(1)，21β-O-angeloyl barring togenol C 和R1-barrigenol。本文由50%之酒精之莖、葉抽取物，經管柱和逆流層析法，再結晶等，得到五個化合物，經光譜和化學等方法鑑定後。從葉中得1，和21β，22α-di-O-angeloyl-R1-barrigenol(2)。從莖中除2外，另得到一個新的化合物21β-Oangcloyl-R1-barrigenol-3β-O-β-D-arabinoside(3)和21β，22α-di-O-angloyl-R1-barrigenol [Mwt.l522]之糖苷（其糖鏈之結構尚待確定)，和Coniferylaldehyde其中2，5為首次在本植物中得到。而3為一新發現的化合物。4的結構亦需更進一步之證明。

The 500% ethyl alcoholic extracts of the stem and leaf of Pittosporum tobira AIT. (Pittosporaceae) were subjected to separation with column and droplet countercurrent chromatography, respectively. Five different solid compounds were isolated. Through experiments of physical, chemical, and spectral characterizations and by comparison with authentic samples of the corresponding compounds, these compounds were identified as 21ß-angeloyl-R1-barrigenol (1) and 21β, 22β-diO-angeloyl-R1-barrigenol (2) from leaves. From the stem we have a1so obtained 2, and a new 21ß-Oangeloy1- R1-barrigenol-3ß-O-ß-D-arabinopyranoside (3), glycoside of 21β, 22α-di-O-angeloyl-R1-barrigenol (Mwt. 1552) (4) as well as conifery1aldehyde (5). But the exact structure of 4 remains to be determined.