小果刀豆對於痔瘡療效的藥理學評估

The Pharmacological Evaluations of the Crude Extracts of Canavalia Microcarpa on Treatment of Hemorrhoids

根據以前中國民間的應用，小果刀豆是一種有效的痔瘡治療劑。本研究試就現代之藥理學技術來探討及評估其藥理作用。結果發現小果刀豆的粗抽取液可減低化學及熱板法所致之疼痛反應；對於離體免耳朵血管可引起顯著的收縮作用；而且對於麻醉大白鼠也具升壓作用。以Lee-White方法測得，小果刀豆具有縮短大白鼠之血液凝集時間。除外對於局部刺激所致的大白鼠的足蹠浮腫，小果刀豆也可以有效抑制作用。由以上結果顯示，小果刀豆對於痔瘡的療效，可能係由鎮痛、抗炎作用及影響血液學所致。其有效成分主要是在水層，至於其結構正進一步分析中。

According to Chinese folk practice, Canavalia microcarpa (CM) was used to treat hemorrhoid effectively. In this study, we investigated and evaluated the pharmacological effects of CM extract by means of modern pharmacological techniques. It was found that CM extract diminished the pain reactions induced by chemical and hot plate methods. CM extract obviously caused constriction of blood vessels in the rabbit ear in vitro. In anesthetized rats, CM extract elevated the arterial blood pressure. Furthermore, it shortened the coagulation time of rat's venous blood as estimated by Lee-White methods. Additionally, CM was also effective in antagonizing inflammation induced by local irritation at rats hind paws.On account of these results, we conclude that Canavalia microcarpa has the potential for the treatment of hemorrhoid through its analgesic, anti-inflammatory and hemostatic effects.The bioactive constituents of Canavalia microcarpa may be present in the H2O layer.