大學新生睡眠品質與疾病和生化檢查值的關係

Relationship between Sleep Quality and Illness and Biomarkers of Disease in University Freshmen

使用匹茲堡睡眠品質量表(Pittsburgh Sleep Quality Index, PSQI)調查571名大學新生接受健康體檢者，以探討睡眠品質與疾病和生化檢查值的關係。我們分析睡眠品質差與有／無氣喘、過敏性鼻炎、心臟病、B型肝炎帶原者、肝功能異常、蛋白尿、血膽固醇過高的關係。171位(29.90％)研究對象PSQI分數大於5，睡眠品質差。有心臟病或B型肝炎帶原者PSQI分數顯著地大於沒有此疾病者的分數（分別是p = .03, .01）。在調整性別與身體質量指數的影響後，比較疾病或生化檢查值異常者發生睡眠品質差的相對危險機率，只有B型肝炎帶原者（風險比為3.59，95％信賴區間1.00～12.93，p = .05）與睡眠品質差有顯著相關。本研究結果顯示大學新生睡眠品質差的盛行率高，心臟病或B型肝炎帶原者的睡眠品質差呼應文獻報告睡眠品質與心臟疾病和肝功能異常的關係。

Pittsburgh Sleep Quality Index (PSQI) was performed in 571 university freshmen who undergone health-screening to examine the relationship between sleep quality and illness and biomarkers of disease. We analyzed the relationship of poor sleep quality to the presence/absence of asthma, allergic rhinitis, heart disease, hepatitis B carrier, liver dysfunction, proteinuria and hypercholesterolemia. One hundred seventy-one subjects (29.90%) showed poor sleep quality with PSQI score over 5. The score of PSQI is significantly greater in subjects with heart disease or hepatitis B carrier than in those without it (p = .03, .01, respectively). Hepatitis B carrier (odds ratio = 3.59, 95% confidence interval 1.00 to 12.93, p = .05) was significantly associated with poor sleep quality after adjustment for sex and body mass index. The present study revealed a high prevalence of poor sleep quality among university freshmen. The associations of poor sleep quality with heart disease or hepatitis B carrier may partially explain the previously reported relationship between sleep quality and heart disease or liver dysfunction.