Mo-so people's dwellings in Yun-nan are precious witness of matriarchal families. This paper takes Luo-shui lower village as an example to illustrate the spatial structure of dwellings and the situation of the use of each space, especially the male's and female's sleeping place. The methodology is based on a review of literature, architectural survey, and interviews, to make clear the interaction between organizational principles and morphological forms during the decades. Further, the authors attempt to look at how the continuity and transformation were seen under the impacts and interactions by outer rulers, introduced religions. It is known that Mo-so people had established their own dwellings on the basis of their social norms and customs with distinctive features in spatial structure between male and female. Although some matriarchal families of Mo-so people transited to paternal families; still they returned back naturally to matriarchal families as we may see. Looking at the procedure of adaptation, it can be suggested that there will be a better opportunity for maintaining the cultural diversity if the cultural features of the spatial structure are kept in the development plan and design.