中國人血管張力素轉化脢基因之刪除／插入多形性現象與心肌梗塞之關係

Angiotensin-I Converting Enzyme Gene Deletion/Insertion Polymorphism and Myocardial Infarction in Taiwan Chinese

在白種人和日本人，ACE基因之刪除多形象為心肌梗塞之獨立危險因子。本實驗之設計以生長在台灣之中國人為研究對象，研究ACE基因之刪除／插入多形性現象和中國人心肌梗塞之關連。本實驗共比較186位心肌梗塞病患及200位正常成人。結果顯示心肌梗塞病患有較高ACE基因同型合子之D/D基因形及刪除多形性比例（20%相對於16%，及42%相對於39%）：但以卡方分析未達統計學意義（p=0.58及0.33）。更進一步比較刪除多形性比例在性別、年齡上之差異，結果亦發現無一組顯示有統計學意義。結論為ACE基因之刪除多形性現象和生長在台灣之中國人之心肌梗塞並無顯著關連，與白種人及日本人之心肌梗塞致病機轉不同。

Deletion polymoprhism of ACE gene is an independent risk factor for myocardial infarction in Caucasian and Japanese. We investigate the role of deletion/insertion (D/I) polymorphism of angiotensin (ACE) gene in the pathogenesis of myocardial infarction in Chinese population living in Taiwan. A case-control study was carried out to examine the association of the ACE gene genotype and allele frequency on 186 patients with myocardial infarction, compared with 200 healthy. Although the frequencies of both homnzygote deletion (DD) genotype and D allele were greater in myocardial infarction than in controls (20% vs 16%, and 42% vs 39%), the differences were not found to be significant by x2 analysis (p=0.58 and 0.33, respectively). Upon further comparison of the frequencies of D allele among two different ages and sexes subgroups, there were still no significant associations. In conclusion, deletion polymorphism of ACE gene was found to play a minor role, different from the Caucasian and Japanese, in the pathogenesis of myocardial infarction in Chinese population living in Taiwan.