SIRT1／PGC－1α分子路徑對於運動調控骨骼肌功能所扮演之角色

The Role of SIRT1/PGC-1α Axis in the Exercise-Regulated Biological Functions of Skeletal Muscle

規律有氧運動具有提升耐力與協助維持心血管健康之功用。而且規律有氧運動對於身體的代謝適應作用與生理結構也都有益處，特別是骨骼肌。因為骨骼肌的型態會影響人體的表現與健康，而且骨骼肌的氧化能力也被視為決定運動耐受性的主要因子。最新研究報告指出，運動調控骨骼肌轉錄作用以及功能再重新塑造的過程中，由Sirtuin1（SIRT1）與過氧化體增生劑活化受體γ輔啟動因子－1α（Peroxisome proliferator activated receptor γ coactivator-1α PGC-1α）所組成的訊息路徑扮演著重要角色。此一分子路徑不僅與骨骼肌纖維型態轉換有關，並且也參與調控提升有氧能力之作用。因此，SIRT1／PGC－1a活性將會直接影響其下游相關基因的表現，並且與骨骼肌粒線體受損所造成的相關疾病關係密切。本篇綜論針對SIRT1／PGC－1a此一訊息路徑在運動誘發骨骼肌粒線體生物合成過程中所扮演之角色作系統性探討。而且本回顧性文章也就目前運動益處的最新分子知識作詳細介紹。

Regular exercise can increase the endurance capacity and improve cardiovascular health. In addition, regular exercise has also been reported to benefit the metabolic adaption and physiological structure, especially in the skeletal muscle. The phenotype of skeletal muscle is associated with human performance and health, and skeletal muscle oxidative capacity is thought to be a key determinant of exercise tolerance in humans. More recently, the protein deacetylase sirtuin 1 (SIRT1), is proposed to be a critical regulator of exercise-induced muscle transcription and remodeling, primarily mediated via its ability to deacetylate and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). The SIRT1/PGC-1α pathway drives the fiber-type switching in skeletal muscle and increases the aerobic capacity. Therefore, the SIRT1/PGC-1alpha activity will directly regulate the downstream genes expression, as well as mitochondrial dysfunction of skeletal muscle involved in tissue responses to injury. The present review systematically investigates the role of SIRT1/PGC-1a signaling pathway in exercisestimulated mitochondrial biogenesis of skeletal muscle tissues. Our review article also provides detail information on recent molecular insights into the benefits of exercise.