Propofol使用相關之急性肺損傷

脂溶性propofol （2,6-diisopropylphenol） 藥物，因其生效快速、藥效持續時間很短之故，因而很適合用於危急病人鎮靜使用，臨床上使用此藥後引起急性肺損傷 （acute lung injury, ALI） 之不良反應很少見，本文描述一個案使用propofol 一次劑量後引發嚴重急性肺損傷，經由氣管插管、呼吸器及葉克膜（extracorporeal membrane oxygenation, ECMO） 輔助治療成功，依據Naranjo 評估propofol 與不良反應之關聯性為7 分屬於很可能，本文藉此個案討論與瞭解相關引發之機轉，同時提醒醫療人員留意罕見之不良反應。

The lipid soluble drug propofol (2,6-diisopropylphenol) because of its fast onset of action and short duration. It is generally used for sedation in the intensive care unit. Acute lung injury after the administration of propofol has rarely been reported. This case in which the administration one dose of propofol was associated with severe lung injury, the patient was treated successfully with mechanical ventilator, ECMO (extracorporeal membrane oxygenation) support. The Naranjo scale, calculated according to the algorithm for adverse drug reaction was 7 and classified as "probable". This case report will further discuss with propofol about adverse drug reaction and underlying mechanisms, to make an alert for medical staff to remind the rarely adverse drug reaction.