| 中文摘要 |
期刊連結：http://www.gouthyperuricemia.org
Purpose: Gout is a chronic inflammatory disease, and gout patients are more likely to develop cancer; here, we review the relationship between the components of gouty inflammation and cancer.
Findings: Multiple steps are required to evoke gouty inflammation, including recognition and uptake of monosodium urate (MSU), ion exchange, inflammasome activation and release of interleukin (IL)-1β and IL-8. Most of the components related to gouty inflammation are associated with carcinogenesis, such as Toll-like receptor (TLR) 2, TLR4, ATP, connexins, pannexins, NLR family pyrin domain containing 3 (NLRP3) inflammasome, IL-1β and IL-8. Controversially, evidence also suggests that TLRs, connexins, NLRP3 inflammasome and IL-1β may be double-edged-swords in the influence of tumor progression.
Conclusion: Most of the components of gouty inflammation are related to carcinogenic, but some of the components exert promoting or inhibiting effects depending different tissues, stages and specific types of cancers. |
