期刊連結：http://www.gouthyperuricemia.org

Objective: The objective of this study is to investigate thyroid function in people with different serum uric acid (SUA) levels, and to further analyze their potential relationship.

Methods: In this cross-sectional study, a total of 4248 health-screening participants treated in Shandong Provincial Hospital affiliated to Shandong University were included. Participants were categorized as hyperuricemic or normouricemic according to their SUA levels, and thyroid dysfunctions were identified according to standard diagnosis guidelines.

Results: There is no statistical difference between thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) and SUA levels in both males and females. The related coefficients of TSH, FT4, and FT3 with SUA are -0.07, 0.15, and 0.21 respectively. The contribution of FT3 to SUA is not statistical significance among multiple factors, and vice versa. The test of prevalence rate between certain thyroid dysfunction and euthyroid in hyperuricemia and normouricemia participants showed no statistical significance and Chi-square test results suggest that the distribution of thyroid function conditions are not different in hyperuricemic and normouricemic participants both in males and females.

Conclusion: The relationships between TSH, FT4, FT3 and SUA are very weak and, among multiple factors, cannot account for hyperuricemia. There is no difference in the prevalence of certain thyroid dysfunction, as well as the distribution of thyroid function conditions in both males and females with various SUA levels in the total population.