期刊連結：http://www.gouthyperuricemia.org

Objective: The present study was designed to investigate the involvement of rs10489070 polymorphism of Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) in gout susceptibility and serum uric acid levels in Chinese Han population.

Methods: We examined 297 primary gout patients, as well as 211 healthy volunteers in this study, and the rs10489070 genotype was evaluated using TaqMan® technology. The genotype distribution and allele frequencies were analyzed between the two groups; the laboratory parameters and clinical data were also compared between different genotypes.

Results: The rs10489070 locus was in Hardy-Weinberg genetic equilibrium in the study population. The genotype distribution and allele frequencies were not statistical different between gout and control subjects (p>0.05). There were also no significant differences in genotype distribution and allele frequencies between 30 tophaceous gout patients and 190 non-tophaceous gout patients (p>0.05). However, serum uric acid (UA) levels in the CC genotype subjects were significantly higher than those with the CG genotype (p<0.05), while apolipoprotein A1 (apoA1) levels in the CC genotype subjects were significantly lower than those with the CG genotype (p<0.05).

Conclusion: Results of present study suggest the rs10489070 polymorphism in SLC2A9 might not be associated with gout susceptibility in Chinese Han population, but involved in the metabolism of UA and apoA1.