| 英文摘要 |
Toxic epidermal necrolysis (TEN) was first reported by Alan Lyell in 1956 and was named as the Ly-ell syndrome. TEN occurs rarely due to a serious adverse drug reaction but with a high mortality rate. The common offending agents include anticonvulsants, antibiotics, allopurinol, and non-steroidal an-ti-inflammatory drugs in Taiwan. The case in this report was a 36-year-old male patient, who received surgery of C7 spinal vascular lesions and long segmental hemorrhagic lesions (from C1 to T1 levels). He was prescribed Ampicillin (Ampolin®) and acetaminophen (Depyretin®) prior to surgery. The patient got a fever, skin eruption, morbilliform rash and bullas during the seven days of the postoperative period. Finally, he was identified to get toxic epidermal necrolysis by the differential diagnosis. The pathogenic mechanisms of TEN are still unclear and the standardized treatment procedures of it are also lacking. The suspected TEN-induced drugs should be discontinued as soon as possible and the patient needs to be appropriately provided with the supportive care. The ways to prevent the com-plications from occurring again in the future include taking notes of the drug allergy history on the medical records to avoid contacting with the allergenic drugs again, and offering the patients and their family the knowledge relates to allergic reactions-induced drugs. Moreover, it is important to remind medical staffs that keeping alarm and observing the adverse drug reactions for patients. |
