本研究旨在檢視透析液低、高鈉濃度（dialysate sodium concentration, DSC），對透析患者透析間期體重增加（interdialytic weight gain, IDWG）與血壓的影響。以病歷回顧的方法，收集中部地區三家透析中心血液透析患者之資料，探討透析液鈉濃度與IDWG 與血壓之相關性。共收集221 人，透析液鈉濃度 ≦138 mEq/L（低鈉透析組）有29 人，≧139 mEq/L（高鈉透析組）有192 人，以獨立樣本t檢定二組之IDWG 與血壓是否有顯著差異。結果：兩組的IDWG 有顯著差異（t = 2.14, p = .03），低鈉透析之IDWG 為2.03 公斤，高鈉透析組之IDWG 為2.49 公斤，即低鈉透析組的IDWG 比高鈉透析組少.46 公斤。二組個案透析前收縮壓、舒張壓、平均動脈壓、透析中發生低血壓與抽筋的次數沒有顯著差異。結論顯示透析液低鈉濃度之患者，傾向有較低的IDWG 與IDWG％。研究結果可以提供臨床專業人員設定較低的DSC，是控制患者IDWG 的方法之一。

The purpose of this study was to determine the most ideal dialysate sodium concentration (DSC) for interdialytic weight gain (IDWG) and blood pressure in chronic hemodialysis patients. A retrospective, descriptive design was employed to investigate the relationship between the DSC and IDWG and blood pressure. Chart reviews were performed to collect data. A total of 221 clients receiving dialysis at three dialysis centers in central Taiwan were included in the study. These clients were grouped according to DSC into the low DSC group (≦low 138 mEq/L; n = 29) and high DSC group (≧139 mEq/L; n = 192). Independent t-test was used to determine the differences in IDWG and blood pressure between the groups. Significant difference in IDWG was found (t = 2.14, p = .03); patients receiving hemodialysis had less IDWG with a low DSC. However, there was no significant difference in pre-dialysis blood pressures for either systolic blood pressure, diastolic blood pressure, or mean arterial pressure. IDWG could be improved when DSC level was set at ≦138 mEq/L.