| 英文摘要 |
Aim: To investigate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) combined with alpha glucosidase inhibitor acarbose on body weight (BW) and metabolic parameters in patients with type 2 diabetes mellitus (T2DM). Methods: Participants in this retrospective study comprised 126 patients with T2DM treated at Changhua Christian Hospital, Taiwan from 2012 to 2013. Patients received either exenatide, a GLP-1 RA, combined with acarbose (n=106) or exenatide only (n=20) for 12 months. Data at the beginning and the end of study period, including BW, body mass index (BMI), duration of diabetes, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), systolic blood pressure (SBP), serum lipid and lipoprotein, were extracted from medical records. Regression model was calculated by generalized estimating equations (GEE). Results: After 12 months, patients treated with the combined regimen had significant reductions in BW, BMI, HbA1c, FBG and SBP (p< 0.05). The Exenatide alone group had significant decrease in FBG. In the adjusted model, both groups together had significant reductions of BW, HbA1c and SBP, but the combined therapy group achieved significantly greater SBP reduction than the exenatide alone group (p< 0.05). Conclusion: Exenatide combined with acarbose achieved significant improvements in more metabolic parameters than exenatide alone within one year of therapy. In particular, acarbose may augment the BP lowering effect of exenatide. |
