| 英文摘要 |
Background: Cancer is the third leading cause of death for adolescents and young adults (AYAs) aged 15-29 years old in Taiwan. This study aimed to investigate the trend of cancer incidence in the AYAs in Taiwan during the period from 1995 to 2011. Methods: Cancer incidence data from 1995 to 2011 were obtained from the Taiwan Cancer Registry. Individual cancers were categorized into specific diagnostic groups and subgroups based on the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) AYA site records. Five-year age-specific incidence rates, world age-standardized rates (ASRs), annual percent changes (APCs), and average annual percent changes (AAPCs) were calculated for AYAs by gender and age groups. The Joinpoint statistical software was used to analyze cancer incidence trends. Results: A total of 24,738 incidence cancer cases, including 11,400 males (46.1%), were collected for data analysis. The age-standardized incidence rates of all cancers were 235.7 and 285.8 per million respectively for males and females (male-to-female ratio: 0.8). The three most common cancers for AYA males were carcinoma of liver and intrahepatic bile ducts (22.5 per million), non-Hodgkin lymphoma (19.7 per million), and germ cell and trophoblastic neoplasms of gonads (18.8 per million). The three leading cancers for AYA females, on the other hand, were thyroid carcinoma (61.5 per million), breast carcinoma (31.4 per million), and gonads carcinoma (15.7 per million). During the 17-year study period, there was a significant increase in incidence of Hodgkin lymphoma for both males and females. For males, there was an increase in incidence of acute lymphoid leukemia, germ cell and trophoblastic neoplasms of gonads, thyroid carcinoma, and carcinoma of kidney. For females, increased incidence was noted in non-Hodgkin lymphoma, osteosarcoma, breast carcinoma, and pancreas carcinoma. Conclusion: Overall, there was an increased incidence for all cancer sites in both male and female AYAs. This study further identified a higher cancer incidence for female AYAs compared to their male counterparts. |
