| 英文摘要 |
Acute bronchiolitis is the most common wheezing disorder during infancy.Incidence of bronchiolitis during infancy can exceed 30%. In a birth cohort study, more than one-third of infants had bronchiolitis before 18 months of age, and one-sixth of infants had more than three bronchiolitis attacks. Infants with onchiolitis had respiratory distress in combination with fever, cough, exerciseand feeding-exacerbation. Causes of bronchiolitis could be categorized into five major subtypes, namely infection, allergy, prematurity, male gender and genetic polymorphisms. Of the causes, infection and genetic polymorphism (e.g., Clara cell protein 10, CC10) play the most important roles; in contrast, allergic sensitization is not the major cause. Only wheezing infants with specific IgE to aeroallergen and atopic dermatitis or whose parents had atopic diseases were considered to have infantile asthma. Wheezing infants without risk factors to asthma usually recovered from wheezing episodes after 3 years of age. |
