Lumbar disc herniation is a common condition, but adjacent segment disease (ASD) without prior surgery is rare. We aimed to reveal the chance of spontaneous regression with adjacent level disc herniation by presenting a case of a 36-year-old woman who experiencing chronic low back pain and subsequent radiation pain in both lower extremities. She did not undergo surgical intervention at first. With dif-ferent complaint, she returned to clinic. Magnetic resonance imaging (MRI) showed spontaneously regressed lumbar herniated disc and a newly developed disc herni-ation at upward adjacent level without surgical intervention. Regression of the lum-bar disc herniation is not a rare condition. For patients that has no absolute indica-tion to surgery, conservative treatment could be attempted first. However, limited research exists on ASD in patients without prior surgery, making it difficult to con-clude whether this patient’s condition is ASD or an unrelated disc degeneration event.