Nurse practitioners (NPs) serve as the right hand of physicians and act as the first line of defense for patient health. Their role is positioned as key collaborators in medical practice, working alongside physicians to provide continuous and integrated care. This underscores the fact that NPs have become an indispensable part of the healthcare system. The work stress faced by NPs includes personal stress, professional and interprofessional stress, as well as organizational and expectation-related pressures. When NPs frequently suppress their own feelings to maintain a professional demeanor, the absence of appropriate coping strategies may lead to a prolonged negative cycle of stress, ultimately impairing their work performance and increases the risk of medical errors. Since work-related stress is inev-itable, identifying suitable and personalized coping strategies is essential for maintaining physical, mental, and emotional well-being. Even in high-pressure work environments, adopting an optimistic approach can help NPs navigate challenges effectively. This study aims to further explore how NPs manage and adapt to work-related stress, providing valuable insights for NPs as well as those aspiring to transition into the role in the future.