國人猴痘疫苗接種後之全身和局部反應與心理感受

Systemic and Local Reactions and Psychological Responses after Monkeypox Vaccination among Taiwanese Population

目的：在2022年，世界發生了一次重大的猴痘疫情爆發，尤其涉及性別與性傾向多元群體。本研究旨在探討不同接種方式產生的全身、局部不良反應及心理影響。

方法：我們在台灣的一家醫學中心於2023年5月至6月之間對即將接種第二劑暴露前預防接種疫苗的成年人進行了線上調查。問卷主要內容為第一次猴痘疫苗接種的生理與心理影響。同時，我們也詢問了第二次接種位置的偏好和影響偏好的可能因素。

結果：共有2,827名受訪者完成了問卷。生理影響中，全身性反應最常見是疲倦、肌肉疼痛和頭痛；局部反應最常見為皮膚變色、發紅、腫脹與搔癢。前臂皮內注射相較其他接種方式，較容易產生局部不良反應，特別是皮膚變色，並導致不同程度的生理、心理影響。“美觀”、“疤痕”和“他人觀點”是影響疫苗注射方式偏好的最重要因素。

結論：本研究顯示了不同猴痘疫苗接種方式不同程度的的全身、局部不良反應。了解影響猴痘疫苗接種方式偏好的因素對緩解接種者的身心壓力至關重要。

 

Aim: A severe outbreak of monkeypox occurred worldwide in 2022, particularly affecting sexual and gender minorities. This study aimed to explore the adverse physical and psychological events associated with different monkeypox vaccination regimens.

Methods: A cross-sectional online survey was conducted from May to June 2023, targeting adults scheduled for their second dose of pre-exposure prophylaxis vaccine against monkeypox, with participants recruited from a medical center in Taiwan. The questionnaire focused on the physical and psychological impacts of the first monkeypox vaccination, with the preferences of the participants for the vaccination regimens of the second vaccination and the factors influencing their preferences also inquired.

Results: A total of 2,827 respondents completed the questionnaire. Among physical impacts, common adverse systemic events included fatigue, myalgia, and headache, while common adverse local events included skin discoloration, erythema, swelling, and itchiness. Intradermal injection in the forearm was associated with a higher incidence of local adverse reactions, especially skin discoloration, leading to varying degrees of physical and psychological impacts. “Beauty,” “scar,” and “perceptions of others” emerged to be the most significant factors influencing preferences for vaccination regimens.

Conclusion: This study identified a range of adverse systemic and local reactions associated with different monkeypox vaccination regimens. Understanding the factors influencing preferences for vaccination regimens is crucial for alleviating the physical and psychological stress of vaccine recipients.