Based on previous research, it has been found that wheelchair users may experience different wheelchair vibration behaviors during earthquakes, ranging from walking, rocking, to the most dangerous behavior—overturning, which can occur in sideways or backward directions. Corresponding to different acceleration amplitudes and excitation frequencies related to the natural frequencies of different building heights, different wheelchair vibration behaviors can be triggered. Among them, higher excitation accelerations and lower frequencies typically associated with taller buildings are more likely to result in wheelchair overturning. This study, through experiments and numerical simulations, has discovered that under the same acceleration amplitude, when the excitation frequency is lower than the highest overturning frequency of the wheelchair, the wheelchair can still overturn. Therefore, the overturning frequency of the wheelchair is within a range of values rather than a specific value. As the acceleration amplitude increases, the highest overturning frequency of the wheelchair also increases, and the low-frequency range expands accordingly. Consequently, different acceleration amplitudes correspond to different ranges of wheelchair overturning frequencies. Finally, the shaking table experimental results of this study indicate that fixing both handrails of the wheelchair with external restraints can effectively prevent the wheelchair from overturning in both backward and sideways directions.