This article describes the nursing process of a heart failure patient who underwent left ventricular assist device implantation and waited for heart transplantation and blood dialysis under double impact. During the nursing period from 2020.10.23 to 2020.11.23, direct care, active care, physical assessment, behavioral observation, conversation, and medical record review were used to identify problems such as hopelessness, lack of knowledge about dialysis, and potential catheter infection. Using Watson’s caring theory, patients and caregivers were assisted through dialysis treatment plans, ECG monitoring observations, individualized care to understand physiological knowledge and learn self-care. They were able to get through the nursing process of waiting for heart transplantation and regular dialysis treatment, turning patients into active ones who accept postoperative life changes and improve their self-care ability and regain their sense of self-worth. It is recommended that in the future, LVAD (left ventricular assist device) patient care standards can be established and relevant education and training can be provided to nursing staff to provide individualized health education models so that patients can safely receive dialysis treatment and improve their quality of life.