Geriatric patients presenting simultaneously with chest pain and dyspnea require careful evaluation for potential medical emergencies. Atypical symptoms can complicate the differential diagnosis pro-cess. We present the case of a 70-year-old man who was admitted with chest pain and dyspnea. The initial differential diagnosis considered included pneumonia, pleural effusion, myocardial infarction, pulmonary embolism, and aortic dissection. During his admission, he became pyrexial with leuko-cytosis, and all his cultures (blood, sputum, pleural effusion) came back negative. He did not respond to empirical antibiotics. Due to a history of trauma, empyema was suspected. Stage III empyema was further diagnosed by imaging, thoracoscopy and pathological tissue examinations. Surgery, antibiot-ics, and breathing exercises were provided and led to a complete recovery. Taking into account other risk factors such as elderly age, chronic cough, chronic kidney disease, and a history of chest trauma, it is essential to consider empyema as a differential diagnosis for proper and instant treatments.