In 2023, 14 hospitals in Taipei and in the North District of Taiwan applied for Hospital and Teaching Hospital Accreditation. An analysis and compilation of the implementation results of the medical center’s mission indicators for Mission Three, “Excellent Medical Quality and Patient Safety,” revealed 4 categories, 9 standards, and 32 scoring instruction items. The majority of the implementation results met the requirements of the scoring instructions. A few hospitals may not have provided explanations in the mission indicator review information sheet or may have been missing some content, but overall, they demonstrated excellent medical quality and patient safety results. Nevertheless, the proportion of each hospital’s investment in medical quality and patient safety relative to its total revenue varied greatly. The number of reports submitted to the Taiwan patient safety reporting system and other hospital-wide reporting systems also differed greatly among hospitals, possibly due to differences in the patient safety notification categories and procedures prescribed by each institution. These aspects may require clearer definition in the future. The medical center accreditation results demonstrated continued improvement in each hospital’s scores, with the differences gradually narrowing. In total, 13 out of the 14 hospitals that applied for medical center accreditation achieved scores that met the accreditation standards, demonstrating a certain level of excellence, particularly in implementing Mission Three’s standards for medical quality and patient safety and achieving good performance. In the future, hospitals should not only implement the medical quality and patient safety goals stipulated by the Ministry of Health and Welfare but also conduct root cause analyses following Taiwan patient safety reporting system in accordance with the Ministry of Health and Welfare’s ""Root Cause Analyses Operational Procedures for Patient Safety Incidents."" Hospitals should identify the root causes of major health and safety incidents or process execution failures and propose specific improvement measures to prevent the recurrence of hazardous incidents.