Acute abdominal pain is one of the most common complaints of patients admitted to emergency unit but the diagnosis of intussusception in adults is really rare. The clinical symptoms include abdominal pain (colic), nausea, vomiting and distension. Obstruction, ischemia, necrosis, or perforation of the bowel could be induced by intussusception, and even deteriorating into peritonitis or sepsis if not be-ing treated properly. The case in this study is a 39-years-old woman presented with acute abdominal pain (colic), vomiting and right lower quadrant abdominal pain. The diagnosis could not be established by medical history taking, physical examination and laboratory survey. Ileocolic intussusception was diagnosed by abdominal computed tomography, and reduction of intussusception was arranged ur-gently. Swollen appendix with inflammation was also noted during the operation, thus appendectomy was performed. The patient was discharged after progressive diet and treatments such as providing ad-equate fluid infusion, wound and pain management. Adult intussusception is rare and lack of specific symptoms. The causes of intussusception are various and often related to tumors or sometimes idio-pathic factors such as infection. It is difficult to diagnose intussusception through physical examina-tion. Therefore, intussusception should be considered when adult experience abdominal colic, nausea, vomiting and distension. Abdominal computed tomography should be arranged as soon as possible, and surgical intervention should be provided appropriately for immediate medical care for patients.