Acute delirium is usually caused by infection, clinically. The case in this study is a 57-year-old woman with fever, confusion, and diarrhea for 3 days. The initial diagnosis was delirium caused by bacterial enteritis. Examinations of feces, blood bacteria culture, computed tomography scan, cerebrospinal flu-id, electroencephalography, and cortisol were all normal. However, high fever, diarrhea, tachycardia, acute unconsciousness with respiratory failure, and general convulsions persisted despite antibiotic treatment was applied. After recalling medical history the patient was suffered from hyperthyroidism and discontinued medication without permission. Furthermore, a Xenetix iodine contrast agent was re-cently administered while symptoms such as high fever, altered consciousness, gastrointestinal hepa-tobiliary disturbance, and tachycardia occurred simultaneously. Therefore, the possibility of a thyroid storm became apparent after applying the thyroid storm 100-point diagnosis scale evaluation. As such, ß sympathetic blockers, reduction of thyroid hormone synthesis, glucocorticoids, and preparations con-taining iodine were administered immediately. After treatments, the consciousness and mental symp-toms of the patient were improved and then successfully discharged. This case suggests that a rapid differential diagnosis by remembering the thyroid storm grading scale as well as relevant predisposing factors shell be considered in early diagnosis. Furthermore, proactive treatments could be utilized to reduce mortality rate and the possibility of multiple organ failure, thereby allowing patients to recover self-care ability in the future.