Workplace violence (WPV) is a serious challenge facing health-care workers. This project used the Analysis, Design, Development, Implementation, and Evaluation model to train nursing staff to handle WPV. This study employed a “WPV Response Checklist” and a “Handling WPV Self-Efficacy Scale” to collect data on nurses’ responses to WPV. The data revealed that before training, the nurses responded to WPV appropriately in only 56.8% of cases, despite them giving their self-efficacy to handle WPV a score of 4.8 out of 10. After collecting the initial data, we provided in-service training, general tips for dealing with violence, a portable card, and WPV drills. The intervention was effective. After the intervention, the percentage of appropriate responses to WPV increased to 97.4%, and self-efficacy scores increased to 6.7 out of 10.