GABAB受體腦炎患者的康復軌跡個案報告

Case report: recovery trajectory of a patient with autoimmune anti-GABAB receptor encephalitis

自體免疫性抗GABAB受體腦炎是一種罕見的疾病，在最初的神經精神症狀發生後，也常伴隨後遺症。我們提出一例經腦脊液檢測證實的抗GABAB受體腦炎病例，並由磁振造影成像 (MRI) 檢測到相應的左顳葉病變。透過長時間追蹤與臨床觀察、多次腦部磁振造影成像和認知功能，持續記錄其康復軌跡，提出縱貫性證據，並且在此個案中，使用重複大劑量皮質類固醇衝擊療法，有效地阻止了患者的疾病惡化並具有良好的反應性。

 

Autoimmune anti-GABAB receptor encephalitis is a rare form of limbic en-cephalitis that typically has an initial neuropsychiatric presentation followed by se-qualae. Here, we present a case of anti-GABAB receptor encephalitis confirmed by cerebrospinal fluid testing and a corresponding left temporal lobe lesion detected by brain magnetic resonance imaging (MRI). Longitudinal evidence from clinical ob-servation, brain MRIs, and the ascending trajectory of his cognitive performance confirmed that the repeated high-dose corticosteroid pulse therapy effectively halted the patient’s disease progression with favorable responsiveness.