Objective: Exploring the factors associated with nursing staff’s knowledge, at-titude, and behavior towards discharge planning in a northern regional hospital. Methods: Designed for a cross-sectional study, a structured questionnaire survey was conducted among 360 clinical nurses who had been practicing for three months in a northern regional hospital in August 2022, Data including personal attribute data, discharge planning knowledge scale, attitude scale and behavior scale were analyzed by univariate ANOVA, correlation coefficient and regression. Results: The knowledge and attitude (r = 0.56,p<.001), attitude and behavior (r =0.43,p<.001)of nurses’ discharge preparation showed moderate positive correlation., there was a significant positive correlation between behavior and knowledge (r = 0.71,p<.001 ). The results of regression analysis showed that the higher the total score of knowledge was, the higher the performance of service preparation was (β=- 0.637,p<.001), and there were statistically significant differences in knowledge, attitude and behavior with or without service experience. Conclusion: From the results of this study, we can see that the availability of educational training and high participa-tion experience not only had a significant effect on the level of understanding and attitude, but also the attitude of those who frequently performed discharge planning was more positive, so provide these nursing staff with sufficient education and training, and through education and training to increase the level of understanding.