This study aims to understand the relationships and influences among different background variables, post-traumatic growth, varying levels of social support, post-traumatic stress symptoms, and mental health in the context of the COVID-19 pandemic. The subjects of the study were those who lived in Taiwan and were over 20 years old. Online questionnaire survey was administered as a research method, with a total number of 413 effective samples. The research instruments used include " Interpersonal Support Evaluation List – 16 item", " Post-traumatic Stress Reaction Index-Short Form ", "Post-traumatic growth inventory- Chinese Version", and "Mental Health BMI Index ". The results of the study are as follows:(1) Taiwanese people experience less traumatic impact from COVID-19. (2) Women, young people or those with traumatic experience in the past have more significant psychological reactions affected by COVID-19. (3) Post-traumatic Growth is positively related to perceived post-traumatic stress. However, the relationship between the two did not exist when PTSD was above a certain level. (4) Social support and Post-traumatic Growth are the predictors of mental health during the COVID-19 epidemic. Based on these findings, recommendations for counseling and guidance to enhance mental well-being are proposed.