Vascular reconstruction, regional debridement and removal of the infected pros-thesis, and antibiotics are traditional treatment of infected vascular graft. Here, we reported a 70-year-old male with type 2 diabetes mellitus, dyslipidemia, coronary ar-tery disease after coronary artery bypass graft, peripheral artery disease with femoral to femoral (F-F) bypass graft, and multiple endovascular treatment such as bilateral iliac artery stents and right femoral artery stent-graft, who presented with infected pseudoaneurysm and infected F-F bypass graft. His condition was not suitable for alternative bypass graft; hence, endovascular stent-graft was performed to maintain perfusion of lower extremities. In brief, he underwent endovascular revascularization of the right external iliac artery (EIA) to superficial femoral artery, and left EIA to left femoral-popliteal bypass graft before removal of infected graft following free flap reconstruction, which was not a conventional treatment fashion. The patient recovered well with no recurrence after follow-up for 10 years. Therefore, this treatment may be used as an alternative to bypass grafting for patients with poor candidate vessels.