Abdominal pain and jaundice are often clinically presumed to be symptoms of biliary tract disease. This case who suffered from abdominal pain and jaundice was initially treated as biliary tract infection. However, due to the exacerbation of abdominal pain and the drop in blood pressure, the computed tomography was urgently arranged, and a rupture of abscess on left lobe was found. Percutaneous transhepatic drainage of abscess was performed and Klebsiella pneumoniae was cultured. Furthermore, the Amoebic hemagglutination test was positive from the blood. After standard drug treatment, the condition was controlled with good prognosis. However, in immunocompetent patients, the simultaneous occurrence of amebic and bacterial liver abscesses in the left lobe of the liver is very rare. Clinically, an immunocompetent patient presents with abdominal pain and jaundice, and those who have high-risk occupations and are exposed to soil or water pollution, amebic liver abscess should be included in the differential diagnosis. Identifying the causes as soon as possible could lead to early diagnose and to avoid the delays in treatment.