Since the Nursing Personnel Act was amended in August 2014, the scope of practice of nurse practitioners is relatively clear, but nurse practitioners still face some difficulties in clinical practice. The first difficulty is that based on the “ Regulations Governing Nurse Practitioners Carrying out Medical Activities under the Supervision of a Physician “ nurse practitioners can prescribe medical orders according to the pre-established medical procedures. However, it is common for nurse practitioners to prescribe medical orders under the oral instructions of physicians in clinical practice without prescribe medical orders, and the action lacks any legal foundation. In February 2023, the Ministry of Health and Welfare announced the amendments to the “ The Practice of Nurse Practitioners Performing Medical Services Under the Supervision of Physicians “. This amendment regulates that the pre-established medical procedure is applicable to the community home care situation. Thus, the second practice difficulty is as followed: Is there any risk of violating the provisions of Article 11 of the Physician Law? Furthermore, the amendments are not clear about the formulating process of the pre-established medical procedures, which may hinder the application of the pre-established medical procedures in the community home care situation. This paper puts forward suggestions for these dilemmas and problems, hoping to complete the legal perspectives of nurse practitioners’ scope of practice, to prevent nurse practitioners from breaking the law, to ensure the safety of their practice, and to improve the safety and quality of care for patients.