Purpose: This study investigated the effectiveness of a project for reducing the high turnover rate of new nursing staff. Because of the rural location of our hospital, talent recruitment and retention are challenging. The high turnover rate of nursing staff exacerbates the human resource shortage problem, which in turn increases training cost and affects quality of care. Materials and Methods: This project targeted the new nursing staff of the hospital and was implemented between January 1, 2018, and April 30, 2019. According to statistics, the turnover rate of new nursing staff was 23.5% (35/149) in 2017, and the main reasons for nurses leaving were (1) personal factors (e.g., work stress and adaptation difficulties) and (2) working environment–related factors (e.g., working far from home or in remote areas). Thus, a nurse retention strategy involving the following measures was formulated: a talent campaign implemented through a creative talent recruitment fair, new recruit care symposiums, and diverse work-pressure reduction measures (including the use of zentangles, mood cards, and interactive inheritance cards that are focused on love). Results: The turnover rate of new recruits decreased from 23.5% (35/149) to 11.3% (7/62), and the target retention rate reached 104.3%. Conclusion: This project is an ongoing project, and during the effective maintenance period from 2020 to 2021, the rate still increased from 10.3% (9/87) to 17.9% (12/67). The findings of this study can serve as a reference for the management of nursing staff.