Purpose: Improving medication reconciliation is listed as one of the goals for quality of care and patient safety, particularly in an aging society with multiple chronic diseases. Materials and Methods: This study enrolled older adults in home care, and the study period was January 1, 2020, to March 31, 2021. From January 1, 2020, to March 31, 2020, the medication reconciliation rate for older adults in home care was only 11.8%. After the collection of up-to-date data, Pareto charts and cause-and-effect diagrams were used to identify the following causes underlying the low reconciliation rate: lack of medication reconciliation guidance tools, lack of primary contact information, lack of implementation of home medication reconciliation procedures, and a lack of medication reconciliation information available during hospitalization. The following intervention strategies were implemented: (1) development of promotional videos on medication reconciliation and health education leaflets, (2) provision of contact cards for designated nurses in the region, (3) establishment of working standards for medication reconciliation, and (4) formulation of edication reconciliation lists. Results: By the end of the study period, the medication reconciliation rate for older adults in home care had increased from 11.8% to 84.6%. The goal achievement rate was 151%. Conclusion: At the 6-month follow-up after the end of the study, the reconciliation rate remained at 82.3%.