Purpose: This retrospective study aimed to explore the risk factors for and causes of unplanned return to the operating room (UROR) during hospitalization.Methods: Data on inpatient surgical patients were collected from 2015 to 2019. Descriptive statistics were used to analyze the patients’ demographic and clinical characteristics and their annual admission rates. A chi-square test, independent t test, and logistic regression analysis were used.Results: The number of instances of UROR and rate of UROR were 658 and 1.25%, respectively.The most frequented departments were dentistry, gynecology, neurology, and surgery, accounting for 77.51% of the total rate. The logistic regression analysis revealed that male sex, older age (using age-adjusted Charlson comorbidity index), poor wound management, and the use of general anesthesia were the risk factors for UROR. Infection, primary surgery failure, and bleeding were the most common causes of UROR.Conclusion: UROR can be used as a key indicator for quality of care in surgery. Hospital administrators and clinicians should recognize the risk factors for UROR and develop appropriate treatment strategies to improve the overall quality of medical care.