After the SARS pandemic, the Taiwan Centers for Disease Control enforced infection control inspections and evaluations and established care quality and patient safety goals for health-care institutions. Implementing protective measures health management for health-care personnel is required for all health-care institutions. Health-care institutions implement standard operating procedures to provide treatment (curative or preventive) to health-care personnel after exposure to patient blood or body fluids or injury by sharp objects. By referencing relevant guidelines and literature worldwide and in response to the current situation in Taiwan, the Taiwan Centers for Disease Control established Healthcare Personnel Vaccination Recommendations to help health-care institutions comprehensively and systematically plan and implement vaccination policies for, and thus ensure the immunity of, health-care personnel. Health-care institutions must maintain proper workforce deployment to provide safe work environments and high-quality patient care. Hospitals must establish comprehensive supervision systems and enforce thorough health monitoring and management policies for health-care personnel to support the normal operation of Taiwan’s medical system and ensure the completion of core tasks in medical care.