Being the main family caregiver means their lives are facing major impacts, changes, and choices throughout the entire caring process. Many family caregivers seem to press the pause button of their lives, and part-take in a completely different way of life. The purpose of the study is to explore the impact of spiritual care intervention on the care process of former primary family caregivers from the care process to the end of their responsibilities. Data collection was used semi-structured in-depth interviews. The subjects had taken the role as a primary family caregiver at least one year and had subsequently ended their responsibility for a minimum of one to a maximum of three years. Six former primary family caregivers were interviewed, among whose gender was equally distributed. Ages ranged from 23 to 61 years old. Five cases come from Christian background and one from traditional folk belief. The validity of the interview outline was agreed upon by experts. The interview scripts are analysed with grounded theory. The results show how care values and life reflections are constantly changing along with the care process. The spiritual challenge during of the care process is similar to the five stages of the grieving process. To provide spiritual care, one can refer to the 3R principles. The inner self-spiritual care of the family caregivers is deeply connected to the individual’s beliefs or social norms, and is an important resiliency factor. The family caregivers are encouraged to actively build connections outwardly, make peace with themselves inwardly, and open up their spirit to receive help from people and God. The spiritual care of relatives and friends for family caregivers are suggested to last beyond the end of the care. Daily active companionship, connection and provision of necessary support can prevent the caregivers from giving up their will to survive due to loss. When professional helpers provide spiritual care, they should treat family caregivers as independent individuals who need to be cared for. This research also proposes future research recommendations.