In view of the severe impact caused by the COVID-19 pandemic and the arrival of the new normal, the 2022–2023 Annual Taiwan Patient Safety Goals for Hospitals have incorporated the experience gained in the past 3 years to adopt new practices. Goal 1 emphasizes strengthening the promotian of TRM (Team Resource Management), through the communication and dissemination of policyrelated information. Goal 2 emphasizes enhancing the resilience of healthcare professionals and organizations, and to prevent medical violence. In addition, healthcare professionals should be aware of the information-related patient safety risks and strengthen reporting of such risks. Goal 3 new aims to "implement integrated care of surgical anesthesia and strengthen teamwork," encouraging enhanced recovery after surgery to improve surgical safety. Goal 4 emphasizes the importance of teamwork in the provision of safe care, which is crucial to the prevention of fall incidents. Goal 6 promotes the use of hand sanitizers, advocating the establishment of response measures for critical epidemic diseases in healthcare organizations. Goal 8 moves with time to use the multi-digital modes to facilitate doctor-patient communication in the post-pandemic era. New goal 9 is to maintain safe maternal and newborn care, emphasizing the ability to identify and deal with high-risk pregnancies. Revisions made to the Annual Taiwan Patient Safety Goals for Hospitals are expected to guide healthcare organizations in improving post-pandemic patient safety.