Multiple studies have indicated that receiving an endovascular thrombectomy (EVT) within 8 hours from the onset of acute ischemic stroke substantially improves the patient’s prognosis and reduces the likelihood of disability. In this study, we analyzed 55 patients with acute ischemic stroke who underwent an EVT between January 1, 2018, and April 30, 2019, at Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. From these patients, 48 were included in the final analysis and 7 were excluded for other reasons, such as having concomitant acute illnesses. According to a literature review, we set our optimum door-to-puncture (D2P) time to within 120 minutes, starting from the arrival at the emergency department to the time of arterial puncture for EVT. The average D2P time for the 48 patients was 173 minutes, and only 10.4% of the patients had a D2P time that was less than 120 minutes (our target), with an average hospital stay of 36.8 days. Room for improvement remained, as indicated by comparisons with data from international studies and from other medical centers in Taipei. Therefore, we formed a multidisciplinary team and identified the causes of the delays, including staff unfamiliarity with the clinical protocol, insufficient manpower for transportation, lack of information technology support, and ineffective communication among different departments. The team then worked together and formulated a nursing staff sign-off checklist for EVT, published educational pamphlets advocating timely interventions for acute stroke for the general public, and invented a head immobilization hood for patients with stroke. A timer was also placed at the triage desk to assist with adherence to the protocol. In addition, an institutional protocol including porter management was established as part of our EVT bundle. After the implementation of such an EVT bundle strategy, 68.8% of our patients had a D2P time of less than 120 minutes (up from 10.4%) and the average D2P time decreased from 173 to 112.6 minutes. In conclusion, by establishing a quality control circle, we not only streamlined the workflow among different departments but also optimized the treatment cycle and provided our patients with the best care possible.