With the rapid technology advancement and intense development of smart healthcare, patient safety incidents triggered by information technology related problems emerge in an endless stream, attracting international attention. In 2020, the Joint Commission of Taiwan (JCT) collaborated with the Emergency Care Research Institute (ECRI) to establish Taiwan’s first Information Technology related Patient Safety (ITPS). ITPS aims to collect information technology related patient safety incidents of healthcare organizations via reporting. In 2021, ITPS received a total of 50 incident cases, with the highest number of incidents in categories of inspection/examination/pathology (40%) and medication (38%). In terms of cause classification, the information system (48%) and system interface (26%) problems were the most common. In order to ensure the accuracy and integrity of the reported incident, a dedicated specialist will communicate with the hospital and clarify specific details of the incident. Then, an expert team will conduct in-depth analysis to identify potential patient safety risks in the hospital’s information system and provide immediate feedback and recommendations with final reports. The expert team will also invite hospitals to share their improvement benchmark experience, jointly explore this emerging field, and create a safe e-healthcare system within the country.