台灣地區懷孕婦女的德國麻疹抗體陽性率及IgG濃度分析

Investigation of Positivity Rate for Rubella Antibodies and Immunoglobulin G Levels among Pregnant Women in Taiwan

孕婦具有對於德國麻疹的免疫力是保護胎兒免於感染的關鍵，本研究分析了2013~2018年間15,989位孕婦的德國麻疹抗體IgG檢驗結果。研究顯示：整體的抗體陽性率為86.2%，於東部地區接受產檢及當地出生的孕婦具有最低的抗體陽性率及IgG濃度；而來自中國大陸的孕婦抗體陽性率及濃度則是最低。隨著抗體濃度下降，於幼兒期接種兩劑MMR疫苗的國籍婦女並沒有達到足夠高的濃度以維持至生育年齡，因此建議低濃度者應追加一劑MMR疫苗注射以確保胎兒免除感染風險。

Pregnant women with rubella immunity are key to preventing rubella virus infection in fetuses. We analyzed 2013–2018 test results for rubella immunoglobulin G (IgG) antibodies from 15,989 pregnant women. The total positive rate for rubella antibodies was 86.2%. Women born and screened in Eastern Taiwan had the lowest antibody positive rates and titers. Furthermore, immigrant pregnant women from China had the lowest antibody positive rate and titers compared to other areas. As a result of the decay of rubella antibodies, two doses of the measles, mumps, and rubella (MMR) vaccine administered during childhood produced an insufficiently protective level of IgG antibodies in Taiwanese women pregnant with their first child. This study recommends that women of childbearing age with low antibody levels receive one booster dose of the MMR vaccine to prevent congenital rubella in their children.