Despite the current combat against the coronavirus disease (COVID-19), bacterial resistance to antibiotics still remains a crucial topic of international attention. Severe infections caused by multidrug-resistant bacteria are increasing continuously, causing major difficulties in treating infections and even medical crises endangering national security. Focusing on epidemiology, mechanism, treatment, and prevention with regard to carbapenem resistance in enteric bacteria (e.g., Escherichia coli and Klebsiella pneumoniae), this study comprehensively introduced the future challenges facing multidrug-resistant bacteria control.
To control multidrug-resistant bacteria, a system for investigating the drug resistance mechanism and epidemiology of multidrug-resistant bacteria in Taiwan can be established for integration with medical records of each hospital and subsequent analysis. Appropriate molecular diagnostic test, microbial identification, antibiotic susceptibility test, and analysis of the correlation of bacterial resistance were conducted with standardized laboratory operations. Data obtained from multidrug-resistant bacteria and antibiotic susceptibility tests and clinical impact data were thoroughly recorded to establish a database, where data are used to produce clinically and epidemiologically applicable surveillance reports. These reports are provided to medical institutions, clinicians, and epidemic prevention authorities on a yearly basis to update the most appropriate infection control plan. These are the crucial tasks in multidrug-resistant bacteria control.
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