Choosing Wisely improves quality of care, reduces medical expenses, prevents overuse and misuse problems of medical care in relation to healthcare quality or medical disputes, and increases the sustainability of the National Health Insurance and medical systems. Since 2020, Kaohsiung Medical University Chung-Ho Memorial Hospital has promoted the Choosing Wisely program as part of the review and improvement mechanism for medical services to ensure their adequacy. Started up by the vice superintendent, we assigned tasks to relevant departments, executed educational programs and held regular meetings. With the assistance of the Medical Safety Management Center and Evidence-Based Medicine Center, we performed topic selection and implemented the Choosing Wisely program for seven clinical teams. All the teams completed the tasks successfully. We held a competition, presentation session, and experience-sharing meetings with other hospitals. The initiation of Choosing Wisely in our hospital enabled clinical professionals to participate meaningfully in peer discussion regarding the adequacy of medical care. Herein, we present our experience and strategies in promoting Choosing Wisely at our hospital, which improved the adequacy of medical services and reduced unnecessary testing, diagnoses, and treatments. This study may serve as a reference for those involved in medical education and medical professions.