Background and purpose: Midgut malrotation and volvulus are rare in infants and difficult to diagnose preoperatively . Ultrasound diagnosis has the advantage of no radiation exposure. Color Doppler documenting the reversal or aberrant the superior mesenteric vein (SMV)/ superior mesenteric artery (SMA) axis is not only predictive but also diagnostic of malrotation of gut. Methods : Admitted a 5-day-old newborn with abdominal distention and bilious emesis. Results : Abdominal sonography demonstrated wrapping of the SMV and bowel loops around the SMA ( "whirlpool sign"). An upper gastrointestinal (UGI) series showed a corkscrew appearance of the duodenum, consistent with malrotation and midgut volvulus. The diagnosis of midgut volvulus and mesenteric malrotation was made. The patient underwent successful midgut reduction surgery smoothly. Conclusion: Ultrasonography has been introduced as an alternative method for the diagnosis of malrotation, with an emphasis on the relationship of the SMV and SMA and the so-called “whirlpool sign” in cases of volvulus.The sonographic whirlpool sign is a valid and highly sensitive sign for the diagnosis of midgut volvulus secondary to malrotation. The whirlpool sign is valuable for the preoperative diagnosis of mesenteric vessel malrotation and midgut volvulus.