Objective: The time required for malpractice lawsuits is generally considered to be excessive. Alternative dispute resolution (ADR) is another resolution path for malpractice disputes. ADR refers to out-of-court approaches to resolve conflicts. As health care and malpractice costs continue to rise, interest in methods such as mediation and arbitration is increasing. This study explored the effects of medical malpractice mediation in Taiwan. Methods: Data covering 2008 to 2018 from the Department of Medical Affairs of the Ministry of Health and Welfare were obtained and classified into three time-based groups: T1(2008–2012; reference group), T2 (2013– 2016), and T3 (2017–2018). A general linear model was adopted, and the outcome measures of the new policy were evaluated in terms of time trends and city-level differences. The dependent variables were the success rate of mediation and the time required for mediation. The independent variables were experience level of the medical–legal dual committee (early experience: n=7; no early experience: n=13), motivation to participate (strong motivation: n=13; weak motivation: n=7), third-party professional evaluation (yes: n = 16; no: n = 4), and urbanization level (urban: n=6; rural: n=11). By using a quasi-experimental design, we compared the outcomes between urban and rural areas. Results: The overall success rates of mediation were 49.95%, 41.29%, 42.80%, 37.43%, and 34.29% during 2014–2018, and the average time required for mediation was 44.38 days. The success rate for ADR participation (45.70%) was significantly higher than that for ADR nonparticipation (26.85%; p=0.038), and the time required for mediation with expert consultations (47.66 days) was significantly longer than that without expert consultations (31.25 days; p=0.05). No significant difference was observed in the mediation success rate or mediation time between urban and rural areas. Conclusions: After the promotion of ADR, the mediation success rate did not increase rapidly. When mediation was applied to third-party dispute analysis and opinions, its success rate and duration increased. However, compared with litigation, mediation was still more efficient.